Article
Phenotypic modifications in ovarian cancer stem cells following Paclitaxel treatment.
Cancer medicine - 1 Dec 2013
Craveiro Vinicius, Yang-Hartwich Yang, Holmberg Jennie C, Joo Won Duk, Sumi Natalia J, Pizzonia John, Griffin Brian, Gill Sabrina K, Silasi Dan-Arin, Azodi Masoud, Rutherford Thomas, Alvero Ayesha B, Mor Gil
Abstract excerpt
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite initial responsiveness, 80% of EOC patients recur and present with chemoresistant and a more aggressive disease. This suggests an underlying biology that results in a modified recurrent disease, which is distinct from the primary tumor. Unfortunately, the management of recurrent EOC is similar to primary disease and does not...
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