Back to search

Article

Inhibition of TERT suppressed proliferation and induced apoptosis in chronic myeloid leukemia cells

2025-01-06

Abstract excerpt

<title>Abstract</title> <p>Purpose The targeting of telomerase in cancer therapy elicits significant attention due to recent findings indicating a correlation between high telomerase activity and adverse cancer outcomes, as well as disease resistance. The precise role of telomerase and its catalytic subunit, human telomerase reverse transcriptase (hTERT), in chronic myeloid leukemia (CML) has not been thoroughly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b4390d95-e8fc-5a6a-b33a-ab9185ff0a7d
DOI
10.21203/rs.3.rs-5754607/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Inhibition of TERT suppressed proliferation and induced apoptosis in chronic myeloid leukemia cellsDOI 10.21203/rs.3.rs-5754607/v1
The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expressionSemantic proximity
Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532Semantic proximity
Inhibition of telomerase using BIBR1532 enhances doxorubicin-induced apoptosis in pre-B acute lymphoblastic leukemia cellsSemantic proximity
Telomerase in hematologic malignancies.Semantic proximity
Telomerase Inhibition Effectively Targets Mouse and Human AML Stem Cells and Delays Relapse following ChemotherapySemantic proximity
Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell linesSemantic proximity
Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.Semantic proximity
Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1Semantic proximity
Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosisSemantic proximity
Down regulation of human telomerase reverse transcriptase (hTERT) expression by BIBR1532 in human glioblastoma LN18 cellsSemantic proximity
Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling PathwaySemantic proximity
Direct Short-Term Cytotoxic Effects of BIBR 1532 on Acute Promyelocytic Leukemia Cells Through Induction of p21 Coupled with Downregulation of c-Myc and hTERT TranscriptionSemantic proximity
Select a neighboring publication to make it the new centre.