Article
SLC-30A9 is required for Zn2+ homeostasis, Zn2+ mobilization, and mitochondrial health.
Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2021
Deng Huichao, Qiao Xinhua, Xie Ting, Fu Wenfeng, Li Hang, Zhao Yanmei, Guo Miaomiao, Feng Yaqian, Chen Ligong, Zhao Yan, Miao Long, Chen Chang, Shen Kang, Wang Xiangming
Abstract excerpt
The trace element zinc is essential for many aspects of physiology. The mitochondrion is a major Zn2+ store, and excessive mitochondrial Zn2+ is linked to neurodegeneration. How mitochondria maintain their Zn2+ homeostasis is unknown. Here, we find that the SLC-30A9 transporter localizes on mitochondria and is required for export of Zn2+ from mitochondria in both Caenorhabditis elegans and human cells. Loss of...
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