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Article

Engineered temperature compensation in a synthetic genetic clock.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Hussain Faiza, Gupta Chinmaya, Hirning Andrew J, Ott William, Matthews Kathleen S, Josic Kresimir, Bennett Matthew R

Abstract excerpt

Synthetic biology promises to revolutionize biotechnology by providing the means to reengineer and reprogram cellular regulatory mechanisms. However, synthetic gene circuits are often unreliable, as changes to environmental conditions can fundamentally alter a circuit's behavior. One way to improve robustness is to use intrinsic properties of transcription factors within the circuit to buffer against intra- and...

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Identifiers

PMID: 24395809
DOI: 10.1073/pnas.1316298111
PMCID: PMC3903251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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