Article
Axoplasmic reticulum Ca(2+) release causes secondary degeneration of spinal axons.
Annals of neurology - 1 Feb 2014
Stirling David P, Cummins Karen, Wayne Chen S R, Stys Peter
Abstract excerpt
OBJECTIVE: Transected axons of the central nervous system fail to regenerate and instead die back away from the lesion site, resulting in permanent disability. Although both intrinsic (eg, microtubule instability, calpain activation) and extrinsic (ie, macrophages) processes are implicated in axonal dieback, the underlying mechanisms remain uncertain. Furthermore, the precise mechanisms that cause delayed...
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