Article
Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types.
Neural development - 8 Jun 2012
Villegas Rosario, Martin Seanna M, O'Donnell Kelley C, Carrillo Simon A, Sagasti Alvaro, Allende Miguel L
Abstract excerpt
BACKGROUND: Understanding the cellular mechanisms regulating axon degeneration and regeneration is crucial for developing treatments for nerve injury and neurodegenerative disease. In neurons, axon degeneration is distinct from cell body death and often precedes or is associated with the onset of disease symptoms. In the peripheral nervous system of both vertebrates and invertebrates, after degeneration of...
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