Article
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial.
Cardiovascular diabetology - 6 Jan 2014
Corella Dolores, Sorlí Jose V, González José I, Ortega Carolina, Fitó Montserrat, Bulló Monica, Martínez-González Miguel Angel, Ros Emilio, Arós Fernando, Lapetra José, Gómez-Gracia Enrique, Serra-Majem Lluís, Ruiz-Gutierrez Valentina, Fiol Miquel, Coltell Oscar, Vinyoles Ernest, Pintó Xavier, Martí Amelia, Saiz Carmen, Ordovás José M, Estruch Ramón
Abstract excerpt
BACKGROUND: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain. METHODS: We analyzed the association between the FAIM2-rs7138803 polymorphism and obesity,...
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