Article
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial.
Cardiovascular diabetology - 7 Jan 2016
Corella Dolores, Asensio Eva M, Coltell Oscar, Sorlí José V, Estruch Ramón, Martínez-González Miguel Ángel, Salas-Salvadó Jordi, Castañer Olga, Arós Fernando, Lapetra José, Serra-Majem Lluís, Gómez-Gracia Enrique, Ortega-Azorín Carolina, Fiol Miquel, Espino Javier Díez, Díaz-López Andrés, Fitó Montserrat, Ros Emilio, Ordovás José M
Abstract excerpt
BACKGROUND: Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian locomotor output cycles protein kaput), one of those core genes, is known to regulate glucose...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.