Article
Statistical inference for Hardy-Weinberg proportions in the presence of missing genotype information.
PloS one - 1 Jan 2013
Graffelman Jan, Sánchez Milagros, Cook Samantha, Moreno Victor
Abstract excerpt
In genetic association studies, tests for Hardy-Weinberg proportions are often employed as a quality control checking procedure. Missing genotypes are typically discarded prior to testing. In this paper we show that inference for Hardy-Weinberg proportions can be biased when missing values are discarded. We propose to use multiple imputation of missing values in order to improve inference for Hardy-Weinberg...
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