Article
Non-random error in genotype calling procedures: implications for family-based and case-control genome-wide association studies.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2008
Anney Richard J L, Kenny Elaine, O'Dushlaine Colm T, Lasky-Su Jessica, Franke Barbara, Morris Derek W, Neale Benjamin M, Asherson Philip, Faraone Stephen V, Gill Michael
Abstract excerpt
The considerable data-handling requirements for genome wide association studies (GWAS) prohibit individual calling of genotypes and create a reliance on sophisticated "genotype-calling algorithms." Despite their obvious utility, the current genotyping platforms and calling-algorithms used are not without their limitations. Specifically, some genotypes are not called due to the ambiguity of the data. Any bias in...
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