Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration.

Neurobiology of disease - 1 Feb 2022

Polissidis Alexia, Koronaiou Effrosyni, Nikolopoulou Georgia, Viel Catherine, Nikatou Maria, Bogiongko Marios, Sardi S Pablo, Xilouri Maria, Vekrellis Kostas, Stefanis Leonidas

Abstract excerpt

Preclinical and clinical studies support a strong association between mutations in the GBA1 gene that encodes beta-glucocerebrosidase (GCase) (EC 3.2.1.45; glucosylceramidase beta) and Parkinson's disease (PD). Alpha-synuclein (AS), a key player in PD pathogenesis, and GBA1 mutations may independently and synergistically cause lysosomal dysfunction and thus, embody clinically well-validated targets of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Glucosylceramidase

Share to Lysosomes

Share to Mutation

Share to Neurodegenerative Diseases

Source

Identifiers

PMID: 34995756
DOI: 10.1016/j.nbd.2022.105612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration.PMID 34995756Read ↗

A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degenerationSemantic proximity Read ↗

A double-hit <i>in vivo</i> model of <i>GBA1</i> viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degenerationSemantic proximity Read ↗

The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.Semantic proximity Read ↗

Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques.Semantic proximity Read ↗

GBA1-Associated Parkinson's Disease Is a Distinct Entity.Semantic proximity Read ↗

Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegenerationSemantic proximity Read ↗

GBA Variants and Parkinson Disease: Mechanisms and Treatments.Semantic proximity Read ↗

AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease modelsSemantic proximity Read ↗

The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice.Semantic proximity Read ↗

Mutant GBA1 expression and synucleinopathy risk: first insights from cellular and mouse models.Semantic proximity Read ↗

AAV delivery of <i>GBA1</i> suppresses α-synuclein accumulation in Parkinson’s disease models and restores motor dysfunction in a Gaucher’s disease modelSemantic proximity Read ↗

Targeting the GBA1 pathway to slow Parkinson disease: Insights into clinical aspects, pathogenic mechanisms and new therapeutic avenues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.