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Delineating pathological pathways in a chemically induced mouse model of Gaucher disease

28 May 2016

Abstract excerpt

Great interest has been shown in understanding the pathology of Gaucher disease (GD) due to the recently discovered genetic relationship with Parkinson's disease. For such studies, suitable animal models of GD are required. Chemical induction of GD by inhibition of acid β-glucosidase (GCase) using the irreversible inhibitor conduritol B-epoxide (CBE) is particularly attractive, although few systematic studies...

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PMID: 27234572
DOI: 10.1002/path.4751

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