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A Review of Trabectedin (ET-743): A Unique Mechanism of Action

21 Jul 2010

Abstract excerpt

Trabectedin (ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata, with a chemical structure characterized by three fused tetrahydroisoquinoline rings. Two of these rings (subunits A and B) provide the framework for covalent interaction with the minor groove of the DNA double helix, whereas the third ring (subunit C) protrudes from the DNA duplex, apparently allowing...

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PMID: 20647340
DOI: 10.1158/1535-7163.mct-10-0263

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