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Raltitrexed induces mitochondrial-mediated apoptosis in SGC7901 human gastric cancer cells

1 Aug 2014

Abstract excerpt

Raltitrexed is a specific inhibitor of thymidylate synthase (TS), which has been considered as a potential chemotherapeutic agent for the treatment of advanced gastric cancer. In the present study, the apoptosis mechanisms of raltitrexed in SGC7901 human gastric cancer cells were investigated. The cytotoxic activity of raltitrexed on SGC7901 cells was determined by cell counting kit-8 (CCK-8) assay. The CCK‑8...

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PMID: 25109431
DOI: 10.3892/mmr.2014.2438

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