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Ectoine enhances recombinant antibody production in Chinese hamster ovary cells by promoting cell cycle arrest

28 Jun 2024

Abstract excerpt

Chinese hamster ovary (CHO) cells represent the most preferential host cell system for therapeutic monoclonal antibody (mAb) production. Enhancing mAb production in CHO cells can be achieved by adding chemical compounds that regulate the cell cycle and cell survival pathways. This study investigated the impact of ectoine supplementation on mAb production in CHO cells. The results showed that adding ectoine at a...

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PMID: 38945523
DOI: 10.1016/j.nbt.2024.06.006

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