Article
In black South Africans from rural and urban communities, the 4G/5G PAI-1 polymorphism influences PAI-1 activity, but not plasma clot lysis time.
PloS one - 1 Jan 2013
de Lange Zelda, Rijken Dingeman C, Hoekstra Tiny, Conradie Karin R, Jerling Johann C, Pieters Marlien
Abstract excerpt
Data on genetic and environmental factors influencing PAI-1 levels and their consequent effect on clot lysis in black African populations are limited. We identified polymorphisms in the promoter area of the PAI-1 gene and determined their influence on PAI-1act levels and plasma clot lysis time (CLT). We also describe gene-environment interactions and the effect of urbanisation. Data from 2010 apparently healthy...
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