Article
PINK1 and its familial Parkinson's disease-associated mutation regulate brain vascular endothelial inflammation.
Journal of molecular neuroscience : MN - 1 May 2014
Yunfu Wang, Guangjian Liu, Ping Zhong, Yanpeng Sun, Xiaoxia Fang, Wei Hu, Jiang Yuan, Jingquan Hu, Songlin Wang, Hongyan Zhang, Yong Liu, Shi Chen
Abstract excerpt
Parkinson's disease (PD) is a debilitating disorder that affects movement. Inflammation-mediated endothelial dysfunction has been found to be involved in neurodegenerative diseases, including PD. More than 40 PTEN-induced putative kinase 1 (PINK1) mutations have been found in PD patients. The effects of PINK1 in vascular inflammation are as yet unknown. In this study, our findings revealed that PINK1 can be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.