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Article

Age-associated alteration of gene expression patterns in mouse oocytes

18 Aug 2004

Abstract excerpt

Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5- to 6-week-old mice with those collected from 42- to 45-week-old mice using the NIA 22K 60-mer oligo microarray. Among approximately 11,000 genes whose transcripts were detected in...

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PMID: 15317747
DOI: 10.1093/hmg/ddh241

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