Article
Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme.
BMC cancer - 31 Dec 2013
Oberstadt Moritz C, Bien-Möller Sandra, Weitmann Kerstin, Herzog Susann, Hentschel Katharina, Rimmbach Christian, Vogelgesang Silke, Balz Ellen, Fink Matthias, Michael Heike, Zeden Jan-Philip, Bruckmüller Henrike, Werk Anneke N, Cascorbi Ingolf, Hoffmann Wolfgang, Rosskopf Dieter, Schroeder Henry W S, Kroemer Heyo K
Abstract excerpt
BACKGROUND: Resistance of the highly aggressive glioblastoma multiforme (GBM) to drug therapy is a major clinical problem resulting in a poor patient's prognosis. Beside promoter methylation of the O6-methylguanine-DNA-methyltransferase (MGMT) gene the efflux transporters ABCB1 and ABCG2 have been suggested as pivotal factors contributing to drug resistance, but the methylation of ABCB1 and ABCG2 has not been...
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