Article
Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors.
Molecular cancer research : MCR - 1 Feb 2014
Labbé David P, Nowak Dawid G, Deblois Geneviève, Lessard Laurent, Giguère Vincent, Trotman Lloyd C, Tremblay Michel L
Abstract excerpt
UNLABELLED: The 20q13 chromosomal region has been previously identified as the hereditary prostate cancer genetic-susceptibility locus on chromosome 20 (HPC20). In this study, the 20q13 region was shown to be frequently co-amplified with the androgen receptor (AR) in metastatic prostate cancer. Furthermore, the AR signaling axis, which plays an essential role in the pathogenesis of prostate cancer, was...
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