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Article

Hyperuricaemia in the Pacific: why the elevated serum urate levels?

Rheumatology international - 1 Jun 2014

Gosling Anna L, Matisoo-Smith Elizabeth, Merriman Tony R

Abstract excerpt

Pacific Island populations, particularly those of Polynesian descent, have a high prevalence of hyperuricaemia and gout. This is due to an inherently higher urate level among these populations with a demonstrated genetic predisposition. While an excess of urate can cause pathology, urate is also important for human health. It has been implicated as an antioxidant, has a neuroprotective role and is involved in...

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PMID: 24378761
DOI: 10.1007/s00296-013-2922-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Hyperuricaemia in the Pacific: why the elevated serum urate levels?PMID 24378761Read ↗

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An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate.Semantic proximity Read ↗

Twenty-eight loci that influence serum urate levels: analysis of association with gout.Semantic proximity Read ↗

Genetic Assessment of Hyperuricemia and Gout in Asian, Native Hawaiian, and Pacific Islander Subgroups of Pregnant Women: Biospecimens Repository Cross-Sectional StudySemantic proximity Read ↗

Sex-specific epigenetic signatures of circulating urate and its increase after BCG vaccinationSemantic proximity Read ↗

An update on the genetics of hyperuricaemia and gout.Semantic proximity Read ↗

Genetic assessment of hyperuricemia and gout in Asian, Native Hawaiian, and Pacific Islander subgroups of pregnant women: biospecimens repository cross-sectional studySemantic proximity Read ↗

The Role of Uric Acid in Human Health: Insights from the Uricase GeneSemantic proximity Read ↗

Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia.Semantic proximity Read ↗

Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects.Semantic proximity Read ↗

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.Semantic proximity Read ↗

Discordant association of the <i>CREBRF</i> rs373863828 minor allele with increased body mass index and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa New ZealandSemantic proximity Read ↗

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