Hyperuricaemia in the Pacific: why the elevated serum urate levels?

doi:10.1007/s00296-013-2922-x

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Article

Hyperuricaemia in the Pacific: why the elevated serum urate levels?

Rheumatology international - 1 Jun 2014

Gosling Anna L, Matisoo-Smith Elizabeth, Merriman Tony R

Abstract excerpt

Pacific Island populations, particularly those of Polynesian descent, have a high prevalence of hyperuricaemia and gout. This is due to an inherently higher urate level among these populations with a demonstrated genetic predisposition. While an excess of urate can cause pathology, urate is also important for human health. It has been implicated as an antioxidant, has a neuroprotective role and is involved in...

Topics

Asian People
Genetic Predisposition to Disease
Gout
Humans
Hyperuricemia
Malaria
Protective Factors
Selection, Genetic

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Open in PubMed

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PMID: 24378761
DOI: 10.1007/s00296-013-2922-x

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