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Article

An ELISA assay with two monoclonal antibodies allows the estimation of free factor H and identifies patients with acquired deficiency of this complement regulator.

Molecular immunology - 1 Apr 2014

Nozal Pilar, Garrido Sofía, Alba-Domínguez María, Espinosa Laura, Peña Antonia, Córdoba Santiago Rodríguez de, Sánchez-Corral Pilar, López-Trascasa Margarita

Abstract excerpt

Complement factor H (FH) serum levels can be affected by the presence of immune complexes of FH with autoantibodies like in autoimmune forms of atypical haemolytic uraemic syndrome (aHUS) or with C3b in homozygous factor I (FI) deficiency. These complexes reduce the amount of free functional circ...

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Source

Identifiers

PMID: 24378252
DOI: 10.1016/j.molimm.2013.11.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24378252-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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