Article
Probability genotype imputation method and integrated weighted lasso for QTL identification.
BMC genetics - 30 Dec 2013
Demetrashvili Nino, Van den Heuvel Edwin R, Wit Ernst C
Abstract excerpt
BACKGROUND: Many QTL studies have two common features: (1) often there is missing marker information, (2) among many markers involved in the biological process only a few are causal. In statistics, the second issue falls under the headings "sparsity" and "causal inference". The goal of this work is to develop a two-step statistical methodology for QTL mapping for markers with binary genotypes. The first step...
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