Article
Each of the four intracellular cysteines of CD36 is essential for insulin- or AMP-activated protein kinase-induced CD36 translocation.
Archives of physiology and biochemistry - 1 Feb 2014
van Oort Masja M, Drost Rinske, Janβen Linda, Van Doorn Jan M, Kerver Jana, Van der Horst Dick J, Luiken Joost J F P, Rodenburg Kees C W
Abstract excerpt
Stimulation of cellular fatty acid uptake by induction of insulin signalling or AMP-kinase (AMPK) activation is due to translocation of the fatty acid-transporter CD36 from intracellular stores to the plasma membrane (PM). For investigating the role of the four Cys-residues within CD36's cytoplasmic tails in CD36 translocation, we constructed CHO-cells expressing CD36 mutants in which all four, two, or one of the...
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