Article
Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity.
PloS one - 1 Jan 2013
Cordon-Obras Carlos, Cano Jorge, González-Pacanowska Dolores, Benito Agustin, Navarro Miguel, Bart Jean-Mathieu
Abstract excerpt
Trypanosoma brucei gambiense infection is widely considered an anthroponosis, although it has also been found in wild and domestic animals. Thus, fauna could act as reservoir, constraining the elimination of the parasite in hypo-endemic foci. To better understand the possible maintenance of T. b. gambiense in local fauna and investigate the molecular mechanisms underlying adaptation, we generated adapted cells...
Topics
- Adaptation, Physiological
- Analysis of Variance
- Animals
- DNA Primers
- DNA, Complementary
- Disease Reservoirs
- Fluorescent Antibody Technique
- Genetic Variation
- Genotype
- Glycoproteins