Article
The role of transferrin-receptor variation in the host range of Trypanosoma brucei.
Nature - 29 Jan 1998
Bitter W, Gerrits H, Kieft R, Borst P
Abstract excerpt
Trypanosoma brucei is a unicellular parasite transmitted between African mammals by tsetse flies. T. brucei multiplies freely in the bloodstream of many different mammals, and survives by antigenic variation of the main component of its surface coat, variant surface glycoprotein (VSG). Trypanosomes take up transferrin through a heterodimeric transferrin receptor, the genes for which are expressed in telomeric...
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