Article
Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk.
Journal of the American College of Cardiology - 13 Mar 2012
Mann Stefan A, Otway Robyn, Guo Guanglan, Soka Magdalena, Karlsdotter Lina, Trivedi Gunjan, Ohanian Monique, Zodgekar Poonam, Smith Robert A, Wouters Merridee A, Subbiah Rajesh, Walker Bruce, Kuchar Dennis, Sanders Prashanthan, Griffiths Lyn, Vandenberg Jamie I, Fatkin Diane
Abstract excerpt
OBJECTIVES: The aim of this study was to evaluate the role of cardiac K(+) channel gene variants in families with atrial fibrillation (AF). BACKGROUND: The K(+) channels play a major role in atrial repolarization but single mutations in cardiac K(+) channel genes are infrequently present in AF fa...
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