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Article

Adeno-Associated Virus Types 5 and 6 Use Distinct Receptors for Cell Entry

1 Jan 2006

Abstract excerpt

The transduction efficiency of adeno-associated virus (AAV) vectors in various somatic tissues is determined primarily by the viral capsid proteins. In contrast to vectors made with AAV type 2 capsids, those having type 5 or 6 capsids show high transduction rates in airway epithelial cells, in a range that should be sufficient for treating lung disease. Here we have compared the properties of vectors made with...

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PMID: 16409121
DOI: 10.1089/hum.2006.17.10

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