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Article

Site-Specific N-Glycosylation on the AAV8 Capsid Protein

17 Nov 2018

Abstract excerpt

Adeno associated virus (AAV) is a versatile gene delivery tool, which has been approved as a human gene therapy vector for combating genetic diseases. AAV capsid proteins are the major components that determine the tissue specificity, immunogenicity and in vivo transduction performance of the vector. In this study, the AAV8 capsid glycosylation profile was systemically analyzed by peptide mass fingerprinting...

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PMID: 30453606
DOI: 10.3390/v10110644

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