Proteomic analysis of PTCH1+/- fibroblast lysate and conditioned culture media isolated from the skin of healthy subjects and nevoid basal cell carcinoma syndrome patients.

doi:10.1155/2013/794028

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Article

Proteomic analysis of PTCH1+/- fibroblast lysate and conditioned culture media isolated from the skin of healthy subjects and nevoid basal cell carcinoma syndrome patients.

BioMed research international - 1 Jan 2013

Ponti Giovanni, Bertazzoni Giorgia, Pastorino Lorenza, Monari Emanuela, Cuoghi Aurora, Bergamini Stefania, Bellei Elisa, Benassi Luisa, Azzoni Paola, Petrachi Tiziana, Magnoni Cristina, Pellacani Giovanni, Loschi Pietro, Pollio Annamaria, Witkowski Alexander Michael, Tomasi Aldo

Abstract excerpt

BACKGROUND: The pathogenesis underlying the increased predisposition to the development of basal cell carcinomas (BCCs) in the context of Gorlin-Goltz syndrome is linked to molecular mechanisms that differ from sporadic BCCs. Patients with Gorlin syndrome tend to develop multiple BCCs at an early age and present with tumors of non-sun-exposed skin. The aim of this study was to compare the proteomic profile of...

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Identifiers

PMID: 24369017
DOI: 10.1155/2013/794028
PMCID: PMC3867831

Genes

PTCH1
MMP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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