Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ultraviolet responses of Gorlin syndrome primary skin cells.

The British journal of dermatology - 1 Aug 2008

Brellier F, Valin A, Chevallier-Lagente O, Gorry P, Avril M-F, Magnaldo T

Abstract excerpt

BACKGROUND: Gorlin syndrome, or naevoid basal cell carcinoma syndrome (NBCCS), is an autosomal dominant disorder associated with mutations in the PTCH1 gene, which encodes the receptor of SONIC HEDGEHOG. In addition to developmental abnormalities, patients with NBCCS are prone to basal cell carcinoma (BCC), the most frequent type of nonmelanoma skin cancer in humans. OBJECTIVES: As ultraviolet (UV) exposure plays...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basal Cell Nevus Syndrome
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Patched-1 Receptor

Share to Patched Receptors

Share to Receptors, Cell Surface

Share to Ultraviolet Rays

Source

Identifiers

PMID: 18510667
DOI: 10.1111/j.1365-2133.2008.08650.x

Genes

PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ultraviolet responses of Gorlin syndrome primary skin cells.PMID 18510667Read ↗

Basal Cell Carcinoma in Gorlin's Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?Semantic proximity Read ↗

Keratinocytes from Gorlin Syndrome-induced pluripotent stem cells are resistant against UV radiation.Semantic proximity Read ↗

Diagnosis and Management of Hereditary Basal Cell Skin Cancer.Semantic proximity Read ↗

Carcinogenesis of basal cell carcinomas: genetics and molecular mechanisms.Semantic proximity Read ↗

Molecular Mechanisms and Targeted Therapies of Advanced Basal Cell CarcinomaSemantic proximity Read ↗

Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in gorlin syndromeSemantic proximity Read ↗

[Basal cell carcinoma. Molecular genetics and unusual clinical features].Semantic proximity Read ↗

Human epidermal stem cells: Role in adverse skin reactions and carcinogenesis from radiation.Semantic proximity Read ↗

Hereditary tumour syndromes featuring basal cell carcinomasSemantic proximity Read ↗

Genetics of basal cell carcinoma.Semantic proximity Read ↗

Recent Advances in Signaling Pathways Comprehension as Carcinogenesis Triggers in Basal Cell CarcinomaSemantic proximity Read ↗

Genetic skin diseases predisposing to basal cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.