Article
Linear basal cell nevus with a novel mosaic PTCH1 mutation.
Experimental dermatology - 1 Jun 2020
Saeidian Amir Hossein, Cohen-Nowak Adam, O'Donnell Megan, Shalabi Doaa, McGuinn Kathleen P, Youssefian Leila, Vahidnezhad Hassan, Niaziorimi Fatemeh, Dasgeb Bahar, Kasper David A, Lee Jason B, Uitto Jouni, Nikbakht Neda
Abstract excerpt
The patched tumor suppressor gene (PTCH1) encodes a receptor, which is a key component of the hedgehog signalling pathway. Mutations in PTCH1 are implicated in the development of sporadic basal cell carcinomas (BCC), as well as those in Gorlin Syndrome. Rarely, BCCs may develop in a linear pattern along lines of Blaschko due to cutaneous mosaicism. In cases in which there are other features of Gorlin syndrome,...
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