Article
Basal Cell Carcinoma in Gorlin's Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?
PloS one - 1 Jan 2015
Gache Yannick, Brellier Florence, Rouanet Sophie, Al-Qaraghuli Sahar, Goncalves-Maia Maria, Burty-Valin Elodie, Barnay Stéphanie, Scarzello Sabine, Ruat Martial, Sevenet Nicolas, Avril Marie-Françoise, Magnaldo Thierry
Abstract excerpt
Basal cell carcinoma (BCC) is the commonest tumor in human. About 70% sporadic BCCs bear somatic mutations in the PATCHED1 tumor suppressor gene which encodes the receptor for the Sonic Hedgehog morphogen (SHH). PATCHED1 germinal mutations are associated with the dominant Nevoid Basal Cell Carcinoma Syndrome (NBCCS), a major hallmark of which is a high susceptibility to BCCs. Although the vast majority of...
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