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Article

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.

PloS one - 16 Nov 2010

Bittner Tobias, Fuhrmann Martin, Burgold Steffen, Ochs Simon M, Hoffmann Nadine, Mitteregger Gerda, Kretzschmar Hans, LaFerla Frank M, Herms Jochen

Abstract excerpt

The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss. By means of long-term two-photon in vivo imaging and confocal imaging, we characterized the spatio-temporal pattern of dendritic spine loss for the first time in 3xTg-AD mice. These mice exhibit an early loss of layer III neurons at 4 months...

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Identifiers

PMID: 21103384
DOI: 10.1371/journal.pone.0015477
PMCID: PMC2982845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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