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Article

Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome

20 Dec 2018

Abstract excerpt

While the importance of Toll-like receptor (TLR) signaling is well established in many autoimmune diseases, the role of TLR activation in Sjögren's syndrome (SS) is poorly understood. Studies in mice and humans reveal that TLRs are potent mediators of inflammation in SS. TLRs are expressed and functional in salivary tissue, and TLRs in peripheral blood cells of SS patients are also upregulated and hyperresponsive...

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PMID: 30671484
DOI: 10.1155/2018/1246818

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