Article
Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation.
Scientific reports - 8 May 2018
Mellor Paul, Marshall Jeremy D S, Ruan Xuan, Whitecross Dielle E, Ross Rebecca L, Knowles Margaret A, Moore Stanley A, Anderson Deborah H
Abstract excerpt
The p85α protein regulates flux through the PI3K/PTEN signaling pathway, and also controls receptor trafficking via regulation of Rab-family GTPases. In this report, we determined the impact of several cancer patient-derived p85α mutations located within the N-terminal domains of p85α previously shown to bind PTEN and Rab5, and regulate their respective functions. One p85α mutation, L30F, significantly reduced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.