Article
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2014
Takasaka Naoki, Araya Jun, Hara Hiromichi, Ito Saburo, Kobayashi Kenji, Kurita Yusuke, Wakui Hiroshi, Yoshii Yutaka, Yumino Yoko, Fujii Satoko, Minagawa Shunsuke, Tsurushige Chikako, Kojima Jun, Numata Takanori, Shimizu Kenichiro, Kawaishi Makoto, Kaneko Yumi, Kamiya Noriki, Hirano Jun, Odaka Makoto, Morikawa Toshiaki, Nishimura Stephen L, Nakayama Katsutoshi, Kuwano Kazuyoshi
Abstract excerpt
Cigarette smoke (CS)-induced cellular senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase, antagonizes this senescence, presumably through the attenuation of insulin-like growth factor (IGF)-Akt signaling. Autophagy controls cellular senescence by eliminating damaged cellular components and is negatively regulated by IGF-Akt signaling...
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