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Association between the polymorphism A/G at position 49 of exon 1 of the CTLA-4 gene and antithyroid antibody production in children with Hashimoto's thyroiditis.

Hormone research in paediatrics - 1 Jan 2012

Kucharska Anna M, Wisniewska Alicja, Popko Katarzyna, Demkow Urszula

Abstract excerpt

UNLABELLED: CTLA-4 gene is considered to be one of the strongest factors determining the predisposition to antithyroid antibody (Ab) production. The aim of the study was to evaluate the association of the polymorphism A/G of exon 1 of CTLA-4 gene and antithyroid Ab level in children with Hashimoto's thyroiditis (HT). MATERIAL AND METHODS: 45 children with HT (aged 14.9 ± 2, range 8.1-7.9) and 55 healthy controls...

Topics

Adolescent
Antibody Formation
Autoantibodies
CTLA-4 Antigen
Child
Exons
Female
Genetic Predisposition to Disease
Genotype
Hashimoto Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Poland

Polymorphism, Single-Stranded Conformational

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Identifiers

PMID: 22922453
DOI: 10.1159/000338997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Association between the polymorphism A/G at position 49 of exon 1 of the CTLA-4 gene and antithyroid antibody production in children with Hashimoto's thyroiditis.PMID 22922453Read ↗

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