Article
Using Aspergillus nidulans to identify antifungal drug resistance mutations.
Eukaryotic cell - 1 Feb 2014
He Xiaoxiao, Li Shengnan, Kaminskyj Susan G W
Abstract excerpt
Systemic fungal infections contribute to at least 10% of deaths in hospital settings. Most antifungal drugs target ergosterol (polyenes) or its biosynthetic pathway (azoles and allylamines), or beta-glucan synthesis (echinocandins). Antifungal drugs that target proteins are prone to the emergence...
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