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Article

Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma.

Cancer discovery - 1 Apr 2015

Xie Xiaoqi, Koh Ju Yong, Price Sandy, White Eileen, Mehnert Janice M

Abstract excerpt

UNLABELLED: Macroautophagy (autophagy hereafter) may promote survival and growth of spontaneous tumors, including melanoma. We utilized a genetically engineered mouse model of melanoma driven by oncogenic BrafV600E and deficiency in the Pten tumor suppressor gene in melanocytes to test the functional consequences of loss of the essential autophagy gene autophagy-related-7, Atg7. Atg7 deficiency prevented melanoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25673642
DOI: 10.1158/2159-8290.CD-14-1473
PMCID: PMC4390491

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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