Article
Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors.
Cell death & disease - 26 Jan 2023
Bhatt Vrushank, Lan Taijin, Wang Wenping, Kong Jerry, Lopes Eduardo Cararo, Wang Jianming, Khayati Khoosheh, Raju Akash, Rangel Michael, Lopez Enrique, Hu Zhixian Sherrie, Luo Xuefei, Su Xiaoyang, Malhotra Jyoti, Hu Wenwei, Pine Sharon R, White Eileen, Guo Jessie Yanxiang
Abstract excerpt
LKB1 and KRAS are the third most frequent co-mutations detected in non-small cell lung cancer (NSCLC) and cause aggressive tumor growth. Unfortunately, treatment with RAS-RAF-MEK-ERK pathway inhibitors has minimal therapeutic efficacy in LKB1-mutant KRAS-driven NSCLC. Autophagy, an intracellular nutrient scavenging pathway, compensates for Lkb1 loss to support Kras-driven lung tumor growth. Here we preclinically...
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