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Article

MEK-Dependent Negative Feedback Underlies BCR–ABL-Mediated Oncogene Addiction

20 Dec 2013

Abstract excerpt

UNLABELLED: The clinical experience with BCR-ABL tyrosine kinase inhibitors (TKI) for the treatment of chronic myelogenous leukemia (CML) provides compelling evidence for oncogene addiction. Yet, the molecular basis of oncogene addiction remains elusive. Through unbiased quantitative phosphoproteomic analyses of CML cells transiently exposed to BCR-ABL TKI, we identified persistent downregulation of growth factor...

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PMID: 24362263
DOI: 10.1158/2159-8290.cd-13-0235

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