Article
Survival and death signals can predict tumor response to therapy after oncogene inactivation.
Science translational medicine - 5 Oct 2011
Tran Phuoc T, Bendapudi Pavan K, Lin H Jill, Choi Peter, Koh Shan, Chen Joy, Horng George, Hughes Nicholas P, Schwartz Lawrence H, Miller Vincent A, Kawashima Toshiyuki, Kitamura Toshio, Paik David, Felsher Dean W
Abstract excerpt
Cancers can exhibit marked tumor regression after oncogene inhibition through a phenomenon called "oncogene addiction." The ability to predict when a tumor will exhibit oncogene addiction would be useful in the development of targeted therapeutics. Oncogene addiction is likely the consequence of many cellular programs. However, we reasoned that many of these inputs may converge on aggregate survival and death...
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