Article
Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling
4 May 2016
Abstract excerpt
Although modern therapeutic strategies have brought significant progress to cancer care in the last 30 years, drug resistance to targeted monotherapies has emerged as a major challenge. Aberrant regulation of multiple physiological signaling pathways indispensable for developmental and metabolic homeostasis, such as hyperactivation of pro-survival signaling axes, loss of suppressive regulations, and impaired...
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