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Article

Genetic mouse models of brain ageing and Alzheimer's disease.

Pharmacology & therapeutics - 1 May 2014

Bilkei-Gorzo Andras

Abstract excerpt

Progression of brain ageing is influenced by a complex interaction of genetic and environmental factors. Analysis of genetically modified animals with uniform genetic backgrounds in a standardised, controlled environment enables the dissection of critical determinants of brain ageing on a molecular level. Human and animal studies suggest that increased load of damaged macromolecules, efficacy of DNA maintenance,...

Topics

Age Factors
Aging
Alzheimer Disease
Animals
Brain
Disease Models, Animal
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
Longevity
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24362083
DOI: 10.1016/j.pharmthera.2013.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24362083-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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