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Article

Genetic mouse models of brain ageing and Alzheimer's disease.

Pharmacology & therapeutics - 1 May 2014

Bilkei-Gorzo Andras

Abstract excerpt

Progression of brain ageing is influenced by a complex interaction of genetic and environmental factors. Analysis of genetically modified animals with uniform genetic backgrounds in a standardised, controlled environment enables the dissection of critical determinants of brain ageing on a molecular level. Human and animal studies suggest that increased load of damaged macromolecules, efficacy of DNA maintenance,...

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PMID: 24362083
DOI: 10.1016/j.pharmthera.2013.12.009

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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