Article
Definitions of the phenotypic manifestations of sickle cell disease.
American journal of hematology - 1 Jan 2010
Ballas Samir K, Lieff Susan, Benjamin Lennette J, Dampier Carlton D, Heeney Matthew M, Hoppe Carolyn, Johnson Cage S, Rogers Zora R, Smith-Whitley Kim, Wang Winfred C, Telen Marilyn J
Abstract excerpt
Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound multiorgan effects. The low prevalence of SCD ( approximately 100,000/US) has limited progress in clinical, basic, and translational research. Lack of a large, readily accessible population for clinical studies has contributed to the absence of standard definitions and diagnostic criteria for the numerous complications of...
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