Article
Hb S/β-Thalassemia in the REDS-III Brazil Sickle Cell Disease Cohort: Clinical, Laboratory and Molecular Characteristics.
Hemoglobin - 1 Jan 2020
Belisário André R, Carneiro-Proietti Anna B, Sabino Ester Cerdeira, Araújo Aderson, Loureiro Paula, Máximo Cláudia, Flor-Park Miriam V, Rodrigues Daniela D O W, Ozahata Mina Cintho, McClure Christopher, Mota Rosimere Afonso, Gomes Moura Isabel C, Custer Brian, Kelly Shannon
Abstract excerpt
We described the clinical, laboratory and molecular characteristics of individuals with Hb S (HBB: c.20A>T)/β-thalassemia (Hb S/β-thal) participating in the Recipient Epidemiology and Donor Evaluation Study (REDS-III) Brazil Sickle Cell Disease cohort. HBB gene sequencing was performed to genotype each β-thal mutation. Patients were classified as Hb S/β0-thal, Hb S/β+-thal-severe or Hb S/β+-thal based on prior...
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