Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.

doi:10.1016/j.ajhg.2013.11.017

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Article

Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.

American journal of human genetics - 2 Jan 2014

Ben Khelifa Mariem, Coutton Charles, Zouari Raoudha, Karaouzène Thomas, Rendu John, Bidart Marie, Yassine Sandra, Pierre Virginie, Delaroche Julie, Hennebicq Sylviane, Grunwald Didier, Escalier Denise, Pernet-Gallay Karine, Jouk Pierre-Simon, Thierry-Mieg Nicolas, Touré Aminata, Arnoult Christophe, Ray Pierre F

Abstract excerpt

Ten to fifteen percent of couples are confronted with infertility and a male factor is involved in approximately half the cases. A genetic etiology is likely in most cases yet only few genes have been formally correlated with male infertility. Homozygosity mapping was carried out on a cohort of 20 North African individuals, including 18 index cases, presenting with primary infertility resulting from impaired...

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Identifiers

PMID: 24360805
DOI: 10.1016/j.ajhg.2013.11.017
PMCID: PMC3882734

Genes

DNAH1

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