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Novel Loss-of-Function Mutations in DNAH1 Displayed Different Phenotypic Spectrum in Humans and Mice.

Frontiers in endocrinology - 1 Jan 2021

Khan Ranjha, Zaman Qumar, Chen Jing, Khan Manan, Ma Ao, Zhou Jianteng, Zhang Beibei, Ali Asim, Naeem Muhammad, Zubair Muhammad, Zhao Daren, Shah Wasim, Khan Mazhar, Zhang Yuanwei, Xu Bo, Zhang Huan, Shi Qinghua

Abstract excerpt

Male infertility is a prevalent disorder distressing an estimated 70 million people worldwide. Despite continued progress in understanding the causes of male infertility, idiopathic sperm abnormalities such as multiple morphological abnormalities of sperm flagella (MMAF) still account for about 30% of male infertility. Recurrent mutations in DNAH1 have been reported to cause MMAF in various populations, but the...

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Dyneins
Exome Sequencing
Infertility, Male
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microtubule Proteins

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PMID: 34867808
DOI: 10.3389/fendo.2021.765639
PMCID: PMC8635859

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