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Novel Biallelic DNAH1 Variations Cause Multiple Morphological Abnormalities of the Sperm Flagella.

DNA and cell biology - 1 Jun 2021

Hu Hua-Ying, Wei Tian-Ying, Feng Zhan-Ke, Li Song-Jun, Zhao Rong, Yi Xiao-Ling, Hu Ti-Ling, Zhao Huan, Li Cun-Xi, Liu Zu-Guo

Abstract excerpt

Sperm motility is vital to human reproduction, and malformed sperm flagella can cause male infertility. Individuals with multiple morphological abnormalities of the flagella mostly have absent, short, coiled, bent, and/or irregular-caliber flagella. In this study, a patient with male infertility underwent a physical examination along with his wife. Genetic testing was performed by whole-exome sequencing of the...

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Infertility, Male
Mutation
Sperm Motility
Sperm Tail

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PMID: 33989052
DOI: 10.1089/dna.2021.0097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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